Temperature-Sensitive Behavior of the Hemagglutinin in a Temperature-Sensitive Mutant Virion of Sindbis
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چکیده
منابع مشابه
Temperature-sensitive mutant vaccines.
Many live virus vaccines derived by empirical routes exhibit temperature-sensitive (ts) phenotypes. The live virus vaccines that have been outstandingly successful in controlling poliomyelitis are the prime example of this phenomenon. The three live attenuated strains developed by Sabin were derived from wild-type isolates by rapid sequential passage at high multiplicity of infection in monkey ...
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After treatment with nitrosoguanidine a mutation to temperature sensitivity was obtained in Tetrahymena pyriformis, syngen 1. The trait is controlled by a recessive allele, ts, at a locus linked to serotype locus T. I S is completely recessive, unlike any other allele studied in this organism, and the heterozygotes do not show vegetative assortment. The cross which revealed the linkage of ts an...
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Characterization of conditionally lethal mutants of alphaviruses, Sindbis virus and Semliki Forest virus, has indicated that in almost all the RNA-negative mutants the temperature-sensitive (ts) defect prevents the formation of active transcription complexes at nonpermissive temperature (40 degrees C), but such complexes retain activity at 40 degrees C if formed first at permissive temperature ...
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In our attempts to characterize a temperature-sensitive mutant (ts-2) of monkey kidney cell line BSC-i, we have provided evidence to show that the mutant was defective in the synthesis or processing of rRNA (45, 28 and 18 s) molecules at 39-5 °C and there was indication that the nucleolar RNA polymerase (I) or some factor associated with its functional activity was thermolabile at the restricte...
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The temperature-sensitive mutation in our Escherichia coli strain C1714 appears to be in a ribosomal protein. The mutation maps at the streptomycin locus. Protein synthesis in intact cells stops immediately when the temperature is shifted from 30 to 42 degrees C. Analysis of polyribosome distributions after shift-up suggests that initiation of protein synthesis is defective at the high temperat...
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ژورنال
عنوان ژورنال: Journal of Virology
سال: 1969
ISSN: 0022-538X,1098-5514
DOI: 10.1128/jvi.4.4.547-548.1969